October 20, 2023Virtual
Engineered for the CRISPR Community
Shaping the Future of Modern Medicine
Welcome to World CRISPR Day 2023
We're thrilled you could join us for the 4th annual celebration of CRISPR technology and advancement, where scientists from around the world showcase their research and breakthroughs in CRISPR each year.
This year, explore and immerse yourself in the cutting-edge advancements of CRISPR technology like never before. Expand your knowledge of the latest CRISPR applications and dive into the captivating world of modern genetic engineering.
We've carefully curated a collection of the most current and informative blogs, podcast episodes, resources, and publications to provide you with a complete understanding of how CRISPR is being harnessed in 2023.
From the Synthego Team:
With so many online events, this year the Synthego Team decided to transform World CRISPR Day from a live, 4-8 hour online event into a 'choose your own adventure' virtual experience. We hope this will provide greater flexibility to explore topics of your interest at your own pace. With our hand-picked selection of new content, we are committed to delivering a premier World CRISPR Day 2023 experience. We truly hope you enjoy!
From the Bench Blog
The year has witnessed monumental advancements in the field of CRISPR, revolutionizing the treatment of genetic and non-genetic diseases through genetic engineering in clinical settings. From groundbreaking developments in disease modeling to navigating the intricacies of clinical trials, the Bench Blog covers it all.
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CRISPR 2023 Breakthroughs: Top Developments in the Field
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Alternatives to CRISPR-Cas9: Nucleases for Next-Gen Therapy
Mark DeWitt and Don Kohn Discuss Their ex vivo CRISPR-based Therapy to Cure Sickle Cell Anemia
Understanding FDA Cell and Gene Therapy Guidance
Advances in CRISPR Disease Modeling: Cells, Organoids, Animals, and More
Understanding CRISPR Clinical Trials: Your Questions Answered
CRISPR Cell and Gene Therapies: Key Challenges in Clinical Development
CRISPR sgRNA for Successful Gene Editing: Discovery to Clinic
Regulatory Trends in Cell and Gene Therapies
CRISPR Cuts Podcast
Discover the captivating stories behind every remarkable research paper, as we delve into in-depth conversations with brilliant and thought-leading scientists. Join us on the CRISPR Cuts Podcast as we uncover the answers to the questions we've all been longing to ask.
Mark DeWitt and Don Kohn Discuss Their ex vivo CRISPR-based Therapy to Cure Sickle Cell Anemia
TJ Cradick Speaks About Their HIV CRISPR Therapy in Trials
Stephanie Cherqui Discusses Clinical Development of CRISPR Therapies for Rare Diseases
Bryan Dechairo Envisions an Accessible Future for CRISPR Diagnostics
Sunil Sharma and Raffaella Soldi Talk CRISPR For Unbiased Drug Screening for Rare Pediatric Cancers
Joe Miano Talks About Prime Editing in Mice
Featured Resources
Check out our curated selection of invaluable resources from Synthego, covering topics ranging from the fundamentals of Cell Engineering to the incredible potential of CRISPR in Cancer Therapy. We've diligently conducted the research with our Featured Resources, so you can dive straight into your experiments with ease.
Regulatory Approval of CRISPR Therapies eBook
GMP sgRNA Manufacturing
Clinical-Grade gRNA for Genomic Medicines: Making Sense of the CRISPR Regulatory Landscape
INDe sgRNA Manufacturing
CRISPR Editing Human Primary Resting CD4+ T Cells with RNPs using Nucleofector® Technology
CRISPR in Cancer Therapy eBook
CRISPR Revolution in Cell & Gene Therapy
Cell Engineering 101
CRISPR Screening 101 eBook
Publication Spotlight
Explore how scientists around the world leverage Synthego's precision gene editing technologies to advance genetic disease research, unravel fundamental biology, illuminate cellular pathways, and much more in our Cited Publications.
A small-molecule PI3Kα activator for cardioprotection and neuroregeneration.
Nature immunology Jun 2023CD4(+) T cell calibration of antigen-presenting cells optimizes antiviral CD8(+) T cell immunity.
Nature biotechnology May 2023Efficient prime editing in mouse brain, liver and heart with dual AAVs.
Nature biomedical engineering May 2023Stable expression of large transgenes via the knock-in of an integrase-deficient lentivirus.
Molecular cell May 2023Unconventional initiation of PINK1/Parkin mitophagy by Optineurin.
Cancer discovery May 2023Li-Fraumeni Syndrome-Associated Dimer-Forming Mutant p53 Promotes Transactivation-Independent Mitochondrial Cell Death.
Molecular cell Jun 2023Ubiquitin-independent proteasomal degradation driven by C-degron pathways.
Cell reports. Medicine Jun 2023Tissue-resident memory CAR T cells with stem-like characteristics display enhanced efficacy against solid and liquid tumors.
PloS one Jan 2023Optimization of gene editing in cowpea through protoplast transformation and agroinfiltration by targeting the phytoene desaturase gene.
Nature communications May 2023Genomic mutation landscape of skin cancers from DNA repair-deficient xeroderma pigmentosum patients.
Science advances May 2023CAGE sequencing reveals CFTR-dependent dysregulation of type I IFN signaling in activated cystic fibrosis macrophages.
Molecular therapy : the journal of the American Society of Gene Therapy Jul 2023Chimeric TIM-4 receptor-modified T cells targeting phosphatidylserine mediates both cytotoxic anti-tumor responses and phagocytic uptake of tumor-associated antigen for T cell cross-presentation.
Proceedings of the National Academy of Sciences of the United States of America May 2023CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice.
Cell reports May 2023Several cell-intrinsic effectors drive type I interferon-mediated restriction of HIV-1 in primary CD4(+) T cells.
Cell reports May 2023Vitamin K-dependent carboxylation regulates Ca(2+) flux and adaptation to metabolic stress in β cells.
eLife May 2023Gene editing and scalable functional genomic screening in Leishmania species using the CRISPR/Cas9 cytosine base editor toolbox LeishBASEedit.
eLife May 2023ARPC5 isoforms and their regulation by calcium-calmodulin-N-WASP drive distinct Arp2/3-dependent actin remodeling events in CD4 T cells.
eLife Feb 2023Centriolar satellites expedite mother centriole remodeling to promote ciliogenesis.
British journal of haematology May 2023Resistance to vincristine in DLBCL by disruption of p53-induced cell cycle arrest and apoptosis mediated by KIF18B and USP28.
Free radical biology & medicine Aug 2023An antioxidant response element regulates the HIF1α axis in breast cancer cells.
The Journal of cell biology Aug 2023Reticular adhesions are assembled at flat clathrin lattices and opposed by active integrin α5β1.
Cells May 2023Multiple and Consecutive Genome Editing Using i-GONAD and Breeding Enrichment Facilitates the Production of Genetically Modified Mice.
Blood advances May 2023Repression of TRIM13 by chromatin assembly factor CHAF1B is critical for AML development.
Molecular oncology May 2023The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
Clinical epigenetics May 2023CRISPR-Cas9 knockout screen identifies novel treatment targets in childhood high-grade glioma.
Molecular cancer research : MCR May 2023ZEB1 is regulated by K811 acetylation to promote stability, NuRD complex interactions, EMT, and NSCLC metastasis.
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